Next, let's take a look at the efficacy and application of Cnidium Monnieri Fruit Extract
Part1. External use
Antibacterial: Osthole has inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and can also weaken the pathogenicity of residual strains of Staphylococcus aureus. It can be used synergistically with matrine to treat trichomonal vaginitis, eczema, psoriasis, etc.
Part2. Oral administration
1.Anti-inflammation:
Osthole has inhibitory effect on Staphylococcus aureus and has a good effect on bacterial inflammation. Combined use of osthole and baicalin to synergistically treat pneumonia caused by Staphylococcus aureus.
Anti-cancer: Osthole can inhibit tumor growth in mouse liver cancer model, induce apoptosis of liver cancer cells through multiple targets and multiple pathways, and enhance anti-tumor immune response in mice with liver cancer; osthole can also kill nasal Pharyngeal cancer cells, lung cancer cells and cervical cancer cells, etc., have inhibitory effects on the growth of various tumor cells. It can be used as an auxiliary anti-cancer.
2. Anti-osteoporosis:
Osthole can significantly promote the proliferation and differentiation of bone marrow mesenchymal stem cells and osteoblasts, and at the same time significantly increase the expression levels of osteocalcin and alkaline phosphatase, thereby promoting bone formation and increasing bone mineral content and bone strength. The effect of osthole on promoting the proliferation and differentiation of osteoblasts is related to the concentration, and the optimal concentration is between 5*10-5M-5*10-4M. In addition, the combination of osthole and puerarin can synergistically treat bone dysplasia and osteoporosis.
3. Effects on the endocrine system:
Osthole can promote the synthesis and secretion of androgen in Leydig cells by regulating the gene transcription of enzymes and receptors related to cell membrane and cytoplasm in the process of androgen synthesis in mouse Leydig cells It can also improve the content of testosterone, follicle-stimulating hormone, and luteinizing hormone in serum, and has an androgen-like effect and a gonadotropin-like effect; Oxidative stress damage, protect the function of ovarian tissue, and enhance the antioxidant capacity of ovarian tissue.
Part3. Biopesticide
Low content of osthole can be used as botanical pesticides, grain protection agents, etc., and as a pesticide, osthole has passed organic certification and can be used in organic product bases. 1% osthole water emulsion has special effects on melons, strawberries, and flower powdery mildew (the control efficiency is about 95%), and it also has a dual effect on vegetable downy mildew and aphids. 4% osthole powder has a good control effect on corn weevil, grain beetle (dù) and adult beetle. Compared with other botanical insecticides, osthole has the advantages of high efficiency and low toxicity.
